YMC-Triart
Hybrid silica based columns ranging from UHPLC to prep.
YMC-Triart phases are based on organic/inorganic hybrid particles that combine the high mechanical stability and efficiency of a silica-based packing material with the robust chemical stability of a polymer-based packing material.
This versatile resin is produced using tightly controlled particle formation technology adapted from micro-reactor technology. The resulting uniform particle and pore size distributions as well as the smooth surface greatly contribute to excellent peak shape and separation reproducibility. In addition, YMC-Triart materials are highly resilient and robust when used at extreme pH, elevated temperature, and high pressure.
With high-level performance in a wide range of conditions, YMC-Triart is considered an ideal first choice column for method development.
Available Formats
Bonded YMC-Triart phases are available in 1.9 µm UHPLC as well as 3 and 5 µm analytical particle sizes, with several preparative options in 10 µm and higher.
All materials can be purchased in prepacked columns and guards as well as various quantities of bulk resin.
Column/guard sizes include*:
- Capillary (< 1 mm ID)
- Analytical (1.0 – 8.0 mm ID)
- Preparative (10 mm ID & above)
*Note: not all combinations of particle size, hardware material, and inner diameter are available. See individual product pages and column listings for specific offerings.
Hardware Materials
YMC-Triart columns can be packed in multiple types of hardware for even further flexibility.
- Standard stainless steel columns & guards
- YMC-Accura columns with bioinert coating
- PEEK-lined stainless steel columns
- High-pressure stainless steel columns
Visit the Hardware Specifications Page for more information about the different hardware options.
YMC-Triart Phase Comparison
Below is an overview of all YMC-Triart phases. For more information about a specific product, including applications and purchase options, click the product name.
| Product Name | Stationary Phase | Bonding | End-capping | Particle Size (µm) | Pore Size (Å) | Carbon Content | pH Range | Typical Applications |
|---|---|---|---|---|---|---|---|---|
| C18 (USP L1) | Trifunctional | Multi-stage | 1.9, 3, 5 | 120 | 20% | 1-12 | acidic, neutral, basic compounds, medium polar compounds, peptides, oligonucleotides, small molecules, amino acids, APIs, sugars | |
| C18 (USP L1) | Trifunctional | Multi-stage | 1.9, 3, 5 | 80 | 25% | 1-12 | stereoisomers and hydrophobic analytes, fatty acids | |
| C18 (USP L1) | Trifunctional | Multi-stage | 1.9, 3, 5 | 300 | – | 1-12 | acidic, neutral, basic compounds | |
| C8 (USP L7) | Trifunctional | Multi-stage | 1.9, 3, 5 | 120 | 17% | 1-12 | acidic, neutral, basic compounds | |
| C4 (USP L26) | Trifunctional | Multi-stage | 1.9, 3, 5 | 300 | – | 1-10 | peptides, proteins, antibodies | |
| phenylbutyl (USP L11) | Trifunctional | Multi-stage | 1.9, 3, 5 | 120 | 17% | 1-10 | aromatic compounds, pharmaceuticals, sweeteners | |
| pentafluorophenyl (USP L43) | Trifunctional | None | 1.9, 3, 5 | 120 | 15% | 1-8 | aromatic stereoisomers, halogenated and polar compounds |
100% aqueous stable (no phase de-wetting for reversed phase)
Larger particle sizes available for direct scale-up
| Product Name | Stationary Phase | Bonding | End-capping | Mode | Particle Size (µm) | Pore Size (Å) | Carbon Content | pH Range | Typical Applications |
|---|---|---|---|---|---|---|---|---|---|
| YMC-Triart Diol-HILIC | dihydroxypropyl (USP L20) | Trifunctional | None | HILIC | 1.9, 3, 5 | 120 | 12% | 2 – 10 | amino acids, water soluble vitamins, sugars, antibodies, proteins, peptides |
| bare silica (USP L3) | None | None | Normal Phase / HILIC | 3, 5 | 120 | – | 2-8 | nucleic acids, amino acids, peptides, proteins, drugs, metabolites |
Larger particle sizes available for direct scale-up
| Product Name | Stationary Phase | Bonding | End-capping | Mode | Particle Size (µm) | Pore Size (Å) | Carbon Content | pH Range |
|---|---|---|---|---|---|---|---|---|
| C18 (USP L1) | Trifunctional | Multi-stage | Reversed Phase | 7, 10, 15, 20 | 120 | 20% | 2-10 | |
| YMC-Triart Prep C8-S | C8 (USP L7) | Trifunctional | Multi-stage | Reversed Phase | 10, 15, 20 | 120 | 17% | 2-10 |
| YMC-Triart Prep Bio200 C8 | C8 (USP L7) | Trifunctional | Multi-stage | Reversed Phase | 10 | 200 | 14% | 2-10 |
| YMC-Triart Prep C4-S | C4 (USP L26) | Trifunctional | Multi-stage | Reversed Phase | 10 | 120 | 14% | 2-10 |
| phenylbutyl (USP L11) | Trifunctional | Multi-stage | Reversed Phase | 10 | 120 | 17% | 2-10 | |
| YMC-Triart Prep SIL | bare silica (USP L3) | None | None | Normal Phase | 10, 15, 20 | 120 | – | 2-8 |
100% aqueous stable (no phase de-wetting for reversed phase)
Additional Resources
Download the brochures below for more information about YMC-Triart products.
- Triart Phase Overview – a quick-reference tool with specifications comparison chart & Tanaka values
- YMC-Triart (U)HPLC Columns – a comprehensive brochure containing detailed information & applications for YMC-Triart columns
- YMC-Triart Prep Phases – information about preparative YMC-Triart resins
- YMC-Accura Triart – learn about our bioinert hardware packed with Triart phases
- YMC-Actus SP Columns – these spring-assisted axial compression columns can be packed and QC tested with Triart resin prior to delivery
- YMC Capillary Columns – Many of our resins – including YMC-Triart – are available in capillary column sizes for Micro and Nano-LC
- YMC-Actus Prep Columns – Triart phases are available packed in our preparative column hardware with inner diameters of 20 – 50 mm
Applications
Below is a sampling of applications featuring YMC-Triart products.
- Analysis of Intact Proteins by MicroLC-MS
- Analysis of commercial monoclonal antibodies by microLC-MS/MS
- Analysis of phosphorylated peptides using a bioinert YMC-Accura Triart C18 column
- Benefit of Scalability of YMC-Triart Prep in Oligonucleotide Separations
- Excellent alkaline CIP-stability of YMC-Triart Prep leads to long lifetime
- High sensitivity allergen detection in wine samples
- High sensitivity peptide analysis using YMC-Triart C18 UHPLC and microLC columns
- HILIC analysis of water-soluble vitamins using YMC-Triart Diol-HILIC
- How to influence oligonucleotide analysis by IP-RP
- HPLC Separation of 9 Kavalactones on YMC-Triart C8
- LC-HRMS analysis of the antisense oligonucleotide Mipomersen (Kynamro®)
- LC-MS/MS analysis of PFAS in human serum
- Separation of oligonucleotides modified with disulfides using YMC-Triart Bio C4
Care & Use Manuals
Follow Care & Use guidelines for optimum performance
LC Columns & Accessories
| Product | Phase / Type | Separation Mode(s) | Pore Sizes | Particle Sizes | pH Range | Available Formats | Link to Order |
|---|---|---|---|---|---|---|---|
| YMC-Triart Bio C18 | C18 | Reversed Phase | 300 Å | 3 µm5 µm1.9 µm | 1 - 12 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart Bio C4 | C4 | Reversed Phase | 300 Å | 3 µm5 µm1.9 µm | 1 - 10 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart C18 | C18 | Reversed Phase | 120 Å | 3 µm5 µm10 µm15 µm20 µm1.9 µm7 µm | 1 - 12 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart C18 ExRS | C18 | Reversed Phase | 80 Å | 3 µm5 µm1.9 µm | 1 - 12 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart C8 | C8 | Reversed Phase | 120 Å200 Å | 3 µm5 µm10 µm15 µm20 µm1.9 µm | 1 - 12 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart Diol-HILIC | Dihydroxypropyl | HILIC | 120 Å | 3 µm5 µm1.9 µm | 2 - 10 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart PFP | Pentafluorophenyl | Reversed Phase | 120 Å | 3 µm5 µm1.9 µm | 1 - 8 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart Phenyl | Phenylbutyl | Reversed Phase | 120 Å | 3 µm5 µm1.9 µm | 1 - 10 | UHPLCAnalytical (1 - 8 mm ID)Preparative (10 mm ID & above)Capillary (< 1 mm ID)Biocompatible | |
| YMC-Triart SIL | Bare Silica | HILICNormal Phase | 120 Å | 3 µm5 µm10 µm | 2 - 8 | Analytical (1 - 8 mm ID)Preparative (10 mm ID & above) |
