Twin Column Technology
YMC offers chromatography systems designed to run batch and continuous (twin-column) processes.
The proven ability to scale up from the benchtop Contichrom CUBE to the production scale Contichrom TWIN means YMC is with you every step of the way.
![Twin Column Train](https://www.ymcamerica.com/wp-content/uploads/2024/07/Twin-Column-Train-900x600.jpg)
Contichrom® CUBE Benchtop System
The Contichrom CUBE is a flexible purification system for process development of (bio-)pharmaceuticals such as monoclonal antibodies, peptides, and oligonucleotides. It enables single-column batch and twin-column counter-current processes such as capture (CaptureSMB®) for monoclonal antibody (mAb) affinity chromatography and MCSGP for peptides.
Features:
- Performs batch, integrated batch, and continuous processes
- Pump flow rates of up to 36 mL/min or 100 mL/min
- Equipped with ChromIQ automation software
- Scales up to the YMC Contichrom TWIN
For more detailed information, view the product page or download our brochure.
![Contichrom CUBE](https://www.ymcamerica.com/wp-content/uploads/2023/11/CUBE-with-UVDs-and-FOXY-and-Thermostats.png)
Contichrom® TWIN Process Scale Systems
YMC’s Contichrom TWIN Platform consists of feature-rich, GMP-ready skids for LPLC and HPLC. Built on our patented twin-column approach to continuous purification, these systems are proven to significantly increase productivity.
The Contichrom TWIN can also be run in single-column batch mode, allowing users to save space and capital equipment costs by purchasing one system that can operate in multiple modes.
![](https://www.ymcamerica.com/wp-content/uploads/2023/02/TWIN-500-MCSGP-HPLC-2-scaled.jpg)
Contichrom TWIN HPLC
- Features patented MCSGP technology for enhanced yield and purity
- Simple, two-column design runs both batch and continuous processes
- Equipped with industry-leading high-pressure pumps
- Ideal for applications such as synthetic peptides, oligonucleotides, and ADCs
- Scale up from the Contichrom CUBE benchtop instrument
Contichrom TWIN LPLC
- Features patented CaptureSMB® technology for significantly faster processing speeds
- Simple, two-column design runs both batch and continuous processes
- Employs industry-leading pumps with digital pump control technology
- Ideal for capture steps using Protein A or IEX separations for most protein purifications
- Scales up from the Contichrom CUBE