Breaking the yield-purity trade-off in chromatography purification of peptides and oligonucleotides

Multi-column chromatography processes show several advantages compared to batch chromatography. Comparison of batch and MCSGP chromatography for the purification of oligonucleotides and peptides showing improvements in yield/purity through MCSGP. The work done with the ETH (Zurich) Institute modeling purification of 10 kg product and is summarized in a free poster.