Bulk Chromatography Resin
Bulk Packing Materials
YMC provides an extensive selection of HPLC and UHPLC stationary phases ranging from 1.9 to 150 µm with various pore sizes and characteristics. We offer multiple solutions for reversed phase, normal phase, ion exchange, size exclusion, and chiral separation. Our packing materials with high density and high loading capacity are suitable not only for HPLC, but also for SFC and SMB chromatography.
Many of our resins can be purchased in LC columns as well as gram to multi-ton quantities of bulk packing material. With a thorough quality control system that ensures excellent lot-to-lot reproducibility, YMC resins allow you to scale up with confidence.
In the sections below, you’ll find specifications and more information about several of our resins. To request a quote or sample, reach out to your local rep or contact our office.
Resources
Download our phase charts for a quick comparison of YMC resins.
YMC Purification Resins Overview
a specification table for YMC’s preparative chromatography resins
Analytical Stationary Phases for RP
a specification table for YMC’s analytical resins for reversed phase chromatography
Analytical Stationary Phases for BioLC
a specification table for YMC’s analytical resins for biochromatography
CHIRAL ART Polysaccharide Derivatives
Preparative scale YMC CHIRAL ART is suitable for conventional column separations, dynamic axial compression (DAC) columns, and simulated moving bed (SMB) systems. YMC CHIRAL bulk material is available in up to several hundred kilograms with YMC’s well-known high quality, reproducibility, and technical support.
- Coated & immobilized polysaccharide phases
- Familiar separation characteristics
- 5, 10, 20 μm particle size
- SFC compatible
YMC-Triart Hybrid Silica Based Phases
YMC-Triart and YMC-Triart Prep are organic/inorganic hybrid silica packing materials for preparative separation. They are the first truly preparative scale hybrid phases available in large lot sizes. Triart resins exhibit excellent durability, allowing for the effective cleaning of the gel with alkaline solution.
- Preparative resin available in C18, C8, C4, and Phenyl phases
- Wide temperature and pH ranges
- High mechanical strength for repeated packing and use with DACs
- 5, 10, 15, 20 μm particle size
MacroSep IEX Q
MacroSep IEX Q is an innovative anion exchange resin for the purification of large biomolecules. The optimized macro-porous structure ensures an efficient purification of particles such as adeno-associated viruses (AAVs), protein complexes, and plasmid DNA (pDNA) molecules.
- Macro-porous structure for the separation of large biomolecules such as AAVs
- Ideal particle size (30 μm) for efficient purifications at improved resolution
- 900 nm (9,000 Å) pore size
- Strong anion exchanger providing high dynamic binding capacity (DBC)
YMC Silica Based Phases
YMC has achieved considerable developments in the production process of its classical silica base. This has given rise to an improved generation of stationary phases with superior physical attributes: YMC*Gel High Grade (HG) series.
- Reduced backpressure due to more uniform particle size distribution
- Higher mechanical stability
- Reversed phase and normal phase resins
- 5, 10, 15, 20 μm particle size
YMC-BioPro® IEX Resins
Based on a porous, hydrophilic polymer bead, our SAX or SCX materials deliver excellent dynamic binding capacity, high recovery, and very low non-specific adsorption. YMC-BioPro IEX Q/S and SmartSep Q/S are ideal for proteins, peptides, mAbs, and other biomolecule separations.
- SCX and SAX phases
- Hydrophilic polymer base particle
- 10, 20, 30, 75 μm particle size
- Protein, peptide, mAb, & oligo purification/polishing
MiniChrom® BioPro Columns are an ideal tool for screening, method development, and sample cleaning. These polypropylene LC columns packed with YMC-BioPro IEX stationary phase material are designed for operating conditions up to 30 °C and 30 bar.Learn More
Comprehensive Chromatography Resin Portfolio
YMC’s portfolio of chromatography resins is engineered for versatile and efficient purification across a variety of applications. With solutions designed for use with proteins, AAVs, mAbs, pDNA, oligos, and more, YMC serves the unique needs of the pharmaceutical, food, nutraceutical, and environmental industries. From reversed phase chromatography to ion exchange, size exclusion, and hydrophobic interaction, our resins offer optimized performance for diverse industry requirements.
High-Performance Chromatography Resins for Advanced Bioprocessing
YMC provides robust and reproducible resins designed for researchers and manufacturers working with complex biomolecules, including recombinant proteins, antibodies, and viral vectors. Engineered to support bioprocess chromatography at any scale—from bench to pilot and large-scale manufacturing—these high-quality resins deliver reliable performance. Whether you’re separating proteins, peptides, or oligonucleotides, YMC offers tailored resin solutions to meet your specific needs.
Specialized Resins for High Purity and Efficiency
YMC’s high-grade silica-based resins are bonded to a high-purity silica gel with a narrow particle size distribution. This ensures lower backpressure, increased productivity, and sharper peaks. Our hybrid-silica phases are made from organic and inorganic hybrid particles that are trifunctionally bonded. These resins exhibit strong mechanical stability even under extreme pH conditions, elevated temperatures, and high-pressure environments.
Process Optimization with Advanced Chromatography Resins
YMC’s trusted chromatography resins have been used to optimize processes across multiple industries such as pharmaceuticals, biopharmaceuticals, and food-related product manufacturing. Applications for our many stationary phases encompass small and large molecules, including purification of building block molecules, active pharmaceutical ingredients (APIs) and natural products. Our quality resins are optimized to deliver high efficiency and loadability while maintaining chemical and mechanical resistance, smooth scalability, and lot-to-lot reproducibility.
Liquid Chromatography Solutions from Lab to Production Scale
YMC is committed to advancing life sciences and society through innovative chromatography resins and techniques. From early development to lab-scale and production-scale purification, our resins are engineered to deliver consistent performance and high-quality results. YMC’s products meet the rigorous demands of analytical chromatography and provide the ability to scale up. Let our expertise in chromatography resin guide your project, backed by YMC’s dedication to science and technological innovation.
