YMC-Pack Diol-NP
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A normal phase alternative to silica.
YMC-Pack Diol-NP is a versatile alternative to silica for normal phase separations and provides much better reproducibility when compared to bare silica material. It shows typical normal phase retention behavior when used with low-polarity mobile phases due to hydroxyl groups on the surface of the stationary phase acting as polar groups.
Hydrogen bonding with the Diol-NP layer is not as strong as with silanols on a bare silica surface. As a result, the bonded layer’s hydroxyl groups provide good selectivity without excessive retention. YMC-Pack Diol-NP can also be used in HILIC-mode with organic/water mobile phases.
Characteristics
- Improved peak shape versus bare silica
- Good selectivity without excessive retention
- High product recovery
- Excellent bonded-phase reproducibility
- Long column lifetime
- High loading with prep material
Applications
Typical applications include: pharmaceutical products, metabolites, phospholipid classes
Analytical Specifications
| YMC-Pack Diol-NP | |
|---|---|
| Stationary Phase | dihydroxypropyl (USP L20) |
| Bonding | Monomeric |
| Mode | Normal Phase |
| Particle Size* | 5 µm |
| Pore Size* | 60, 120 Å |
| pH Range | 2 – 7.5 |
| Temperature Upper Limit | 50 °C |
| Temperature Recommended Range | 20 – 40 °C |
*not all combinations of particle & pore size are available
Preparative Specifications
| YMC-Pack Diol-NP-HG | |
|---|---|
| Stationary Phase | dihydroxypropyl (USP L20) |
| Bonding | Monomeric |
| Mode | Normal Phase |
| Particle Size* | 10, 15, 20, 50 µm |
| Pore Size* | 120, 200, 300 Å |
| pH Range | 2 – 7.5 |
*not all combinations of particle & pore size are available
YMC-Pack Diol-NP with particle sizes of 10 µm and higher are available as part of the YMC*Gel High Grade (HG) series. These resins boast improved mechanical stability as well as narrower particle size and pore size distribution.
YMC-Pack Diol-NP-HG can be purchased in prepacked analytical and preparative columns or in bulk resin format.
Available Formats
- Prepacked columns & guards
- Capillary (< 1 mm ID)
- Analytical (1.0 – 8.0 mm ID)
- Preparative (10 mm ID & above)
- Bulk resin
