Contichrom TWIN HPLC
YMC Contichrom® TWIN HPLC
Featuring patented MCSGP technology for enhanced yield and purity
The YMC Contichrom® TWIN HPLC system is designed around our two-column continuous process principle. This technology accelerates validation, simplifies maintenance, reduces costly down-time, and minimizes operating expenses.
In addition to the feature-rich standardized platform, YMC can provide customized solutions to address your specific needs. We employ a team of seasoned engineers, fabricators, and technicians to design and build every system – all under one roof.
What is MCSGP?
MCSGP (Multi-column Counter-current Solvent Gradient Purification) is a two-column process in which side fractions that contain impure product are internally (automatically) recycled in a periodic closed-loop process while pure product is continuously extracted. This eliminates the need for repeated chromatography and the associated time and resources for sampling and testing.
The result?
- Little product is lost
- Pure product yield is maximized without any accumulation of impurities
- Target purity is retained
Contichrom TWIN HPLC Benefits and Specifications
- Industry-leading high-pressure pumps
- Panel design allows for use in hazardous locations
- Wide range of pressure and flow rates
- Improved yield by up to 30-60%
- Reduced solvent consumption
- Significant increase in productivity
- Considerable savings in the collection, storage, analysis, and blending or reprocessing of side fractions
YMC also offers the following options to enhance the system:
- Additional inlet and outlet (fraction) valves
- Filters
- Pre-Column analytics
- Hazardous location design
- Sampling valves
- Automation through customer-selected integrator (YMC would assist in developing a functional specification.)
Additional customizations available upon request.
Industry-Leading High-Pressure Pumps
The Contichrom TWIN HPLC is manufactured using Industry-leading high-pressure pumps that deliver maximum durability, flow accuracy, and precision throughout a wide gradient range.
Maximum operating pressure: 80 bar
Ambient temperature range: 4 – 25 °C
Process temperature range: 4 – 65 °C
| System (HPLC) | Flow rate range* (LPM) |
Column ID range (cm) |
||
|---|---|---|---|---|
| Contichrom TWIN 100 | .01 | .67 | 5 | 10 |
| Contichrom TWIN 300 | .03 | 3.33 | 10 | 20 |
| Contichrom TWIN 500 | .13 | 8.33 | 20 | 45 |
| Contichrom TWIN 1000 | .29 | 16.67 | 30 | 60 |
Quality and Regulatory Considerations
As with all Contichrom platform equipment, the Contichrom TWIN HPLC system is built to meet high quality expectations. The design and construction of the equipment meet the following standards, assuring a safe, ergonomic system capable of performing within the guidelines of the FDA:
- System designed for GMP operation and validation
- Enables 21 CFR part 11 compliance
- USP Class VI materials and seals
- Digitally controlled metering pumps
- Operation in Class I Div. II / ATEX
Interested in Learning More?
For more information about this or our other chromatography systems, contact us or visit one of these related pages:
Contichrom TWIN HPLC
Custom multi-column / continuous chromatography system for HPLC
YMC Single Column LPLC
Custom single-column / batch chromatography system for LPLC
YMC Single Column HPLC
Custom single-column / batch chromatography system for HPLC
Designed and developed by
